Martine M Mirrione

Martine M Mirrione

Assistant Professor of Biomedical Sciences

BS, Marist College; PhD, SUNY at Stony Brook

Biomedical Sciences
Echlin Center  231

(203) 582-8117


BMS 320   Pharmacology   -   Fall 2016
BMS 472   Biotechnology   -   Fall 2016
BMS 502   Research Methods   -   Fall 2016

Educational Background

BS in Biology, Marist College, Poughkeepsie, NY

PhD in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, NY

All Publications

Peer-reviewed – Research Publications

*Li B, *Piriz J, *Mirrione M, *Chung C, Proulx C, Schulz D, Henn F, Malinow R. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature. 2011 Feb 24:470(7335):535-9. *authors contributed equally PMID: 21350486

Emmetsberger J, Mirrione MM, Zhou C, Fernandez Monreal M, Tsirka SE. Tissue Plasminogen Activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4. Journal of Neuroscience. 2010 May 12;30(19):6538-47. PMID: 20463217

Mirrione MM, Konomos D, Gravanis I, Dewey SL, Heppner FL, Aguzzi A, Tsirka SE. Microglial ablation and lippoplysaccharide preconditioning affects pilocarpine-induced seizures in mice. Neurobiology of Disease. 2010 Jul;39(1):85-97. Epub 2010 Apr 9. PMID: 20382223

Schulz D, Mirrione MM, Henn FA. Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl. Neurobiology of Learning and Memory. 2010 Feb;93(2):291-301. Epub 2009 Nov 29. PMID: 19931627

Mirrione MM, Schiffer WK, Fowler JS, Alexoff DL, Dewey SL, Tsirka SE. A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator. Neuroimage. 2007 Oct 15;38(1):34-42. PMID: 17707126

Schiffer WK, Mirrione MM, Dewey SL. Optimizing experimental protocols for behavioral neuroimaging in rodents. Journal of Nuclear Medicine. 2007 Feb;48(2):277-87. PMID: 17268026

Schiffer WK, Mirrione MM, Biegon A, Alexoff DL, Patel V, and Dewey SL. Serial microPET measures of the metabolic reaction to a microdialysis probe implant. Journal of Neuroscience Methods. 2006 Sep 15;155(2):272-8. PMID: 16519945

Mirrione MM, Schiffer WK, Siddiq M, Dewey SL, and Tsirka SE. PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy. Synapse. 2006 Feb;59(2):119-21. PMID: 16320304

Peer-Reviewed – Book Chapters and Reviews

Mirrione MM, Tsirka SE. Neuroimaging in animal seizure models with 18FDG PET. Epilepsy Research and Treatment, Dr. H.E. Scharfman (Ed.), Volume 2011 (2011), Article ID 369295, 8 pages doi:10.1155/2011/369295

Mirrione MM, Tsirka SE. A Functional Role for Microglia in Epilepsy, Clinical and Genetic Aspects of Epilepsy, Dr. Zaid Afawi (Ed.), ISBN: 978-953-307-700-0, InTech, 2011. Available from:

McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, España RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S. Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference. Behavioral Brain Research. 2011 Nov 20;225(1):348-57. Epub 2011 Jul 26. PMID: 21816177

Research Interests

  • Neuroscience
  • Pharmacology
  • Neuroimaging
  • Behavior

I am interested in exploring the neuronal circuits underlying depressive-like behavior and examining the mechanisms related to the therapeutic efficacy of deep brain stimulation for treating depression.

Postdoctoral Experience

Neuroscience Department at Cold Spring Harbor Laboratory (2010-2013)

Medical Neuroimaging Department at Brookhaven National Laboratory (2007-2010)

Teaching & Research Philosophy

In the classroom and laboratory setting, my goal is to engage student interest by creating a lively interactive atmosphere for maximizing the learning potential of each individual student.

My approach includes using visuals to help students learn important principles and concepts, connecting ideas with hands-on experiments, and challenging students with in class questions and activities.

Throughout my basic science education and training, I have also realized that I very much enjoy mentoring students on research projects particularly in my favorite areas, pharmacology and neuroscience.

I am delighted to help students realize the joy of scientific exploration, practice critical thinking, promote well controlled and well powered experiments, and develop communication skills through disseminating scientific data.