Martine M Mirrione

Martine M Mirrione

Assistant Professor of Biomedical Sciences

BS, Marist College; PhD, SUNY at Stony Brook

Biomedical Sciences
Echlin Center  231

(203) 582-8117

BMS 320   Pharmacology   -   Fall 2016
BMS 320   Pharmacology   -   Spring 2017
BMS 472   Biotechnology   -   Fall 2016
BMS 472   Biotechnology   -   Spring 2017
BMS 502   Research Methods   -   Fall 2016
BMS 502   Research Methods   -   Spring 2017

Educational Background

BS in Biology, Marist College, Poughkeepsie, NY

PhD in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, NY

All Publications

Peer-reviewed – Research Publications

*Kim Y, *Perova Z, *Mirrione MM, Pradhan K, Henn FA, Shea S, Osten P and Li B. (2016), Whole-Brain Mapping of Neuronal Activity in the Learned Helplessness Model of Depression. Frontiers in Neural Circuits, 10(3), 1-11. *authors contributed equally PMID: 26869888

Mirrione MM, Schulz D, Kapidus K, Zhang S, Goodman W, Henn FA. (2014), Increased metabolic activity in the septum and habenula during stress is linked to subsequent expression of learned helplessness behavior. Frontiers in Human Neuroscience, 8(29), 1-8. PMID: 24550809

*Li B, *Piriz J, *Mirrione M, *Chung C, Proulx C, Schulz D, Henn F, Malinow R. (2011),Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature. 470(7335):535-9. *authors contributed equally PMID: 21350486

Emmetsberger J, Mirrione MM, Zhou C, Fernandez Monreal M, Tsirka SE. (2010) Tissue Plasminogen Activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4. Journal of Neuroscience. 30(19):6538-47. PMID: 20463217

Mirrione MM, Konomos D, Gravanis I, Dewey SL, Heppner FL, Aguzzi A, Tsirka SE. (2010) Microglial ablation and lippoplysaccharide preconditioning affects pilocarpine-induced seizures in mice. Neurobiology of Disease. 39(1):85-97. PMID: 20382223

Schulz D, Mirrione MM, Henn FA. (2010) Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl. Neurobiology of Learning and Memory. 93(2):291-301. PMID: 19931627

Mirrione MM, Schiffer WK, Fowler JS, Alexoff DL, Dewey SL, Tsirka SE. (2007) A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator. Neuroimage. 38(1):34-42. PMID: 17707126

Schiffer WK, Mirrione MM, Dewey SL. (2007) Optimizing experimental protocols for behavioral neuroimaging in rodents. Journal of Nuclear Medicine. 48(2):277-87. PMID: 17268026

Schiffer WK, Mirrione MM, Biegon A, Alexoff DL, Patel V, and Dewey SL. (2006) Serial microPET measures of the metabolic reaction to a microdialysis probe implant. Journal of Neuroscience Methods. 155(2):272-8. PMID: 16519945

Mirrione MM, Schiffer WK, Siddiq M, Dewey SL, and Tsirka SE. (2006) PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy. Synapse. 59(2):119-21. PMID: 16320304

Peer-Reviewed – Book Chapters and Reviews

Mirrione MM, Tsirka SE. (2011) Neuroimaging in animal seizure models with 18FDG PET. Epilepsy Research and Treatment, Dr. H.E. Scharfman (Ed.), Volume 2011, Article ID 369295, 8 pages doi:10.1155/2011/369295

Mirrione MM, Tsirka SE. (2011) A Functional Role for Microglia in Epilepsy, Clinical and Genetic Aspects of Epilepsy, Dr. Zaid Afawi (Ed.), ISBN: 978-953-307-700-0, InTech. Available from:

McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, España RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S. (2011) Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference. Behavioral Brain Research. 225(1):348-57. PMID: 21816177

Peer-Reviewed – Pedagogical Material

Mirrione MM, Ruth N, Alexoff D, Logan J, Fowler J, Kernan M. (2014, spring), Positron Emission Tomography (PET) and Graphical Kinetic Data Analysis of the Dopamine Neurotransmitter System: An Exercise for an Undergraduate Laboratory Course. The Journal of Undergraduate Neuroscience Education (JUNE) , 12(2), A114-A122. PMID: 2686988

Research Interests

  • Neuroscience
  • Pharmacology
  • Neuroimaging
  • Behavior

I am interested in exploring the neuronal circuits underlying depressive-like behavior and examining the mechanisms related to the therapeutic efficacy of deep brain stimulation for treating depression.

Postdoctoral Experience

Neuroscience Department at Cold Spring Harbor Laboratory (2010-2013)

Medical Neuroimaging Department at Brookhaven National Laboratory (2007-2010)

Teaching & Research Philosophy

In the classroom and laboratory setting, my goal is to engage student interest by creating a lively interactive atmosphere for maximizing the learning potential of each individual student.

My approach includes using visuals to help students learn important principles and concepts, connecting ideas with hands-on experiments, and challenging students with in class questions and activities.

Throughout my basic science education and training, I have also realized that I very much enjoy mentoring students on research projects particularly in my favorite areas, pharmacology and neuroscience.

I am delighted to help students realize the joy of scientific exploration, practice critical thinking, promote well controlled and well powered experiments, and develop communication skills through disseminating scientific data.