Marathons can stress the kidneys, research shows

Runners participating in a marathon

Get a move on

Quinnipiac and Yale researchers found a possible link between the stress, the elevated body temperature and the decreased blood flow to the kidneys during exertion and a short-term reduction in kidney function.


he face of someone who just ran a marathon is unmistakable. It’s a stirring mix of elation and exhaustion, a mask of honor for surviving 26.2 miles.

During warmer weather, the impact of running a marathon could be even more profound, especially on the kidneys, according to a recent study published in the American Journal of Kidney Disease.

Researchers from Quinnipiac and Yale studied 22 volunteers for acute kidney injury, both men and women who ranged in age from 22 to 63. The volunteers were runners who finished the 2015 Hartford Marathon. The researchers found a possible link between the stress, the elevated body temperature and the decreased blood flow to the kidneys during exertion and a short-term reduction in kidney function.

Quinnipiac’s research was performed by Thomas Martin, associate professor of biomedical sciences and a 2017 Faculty Scholar; Rachel Pata, clinical assistant professor of physical therapy; and Karen Myrick, associate professor of nursing. They were assisted by students from the School of Health Sciences, the School of Nursing, and the Frank H. Netter School of Medicine.

“There is a physiological reason why you feel so horrible after running a marathon. It’s because your skeletal muscles, your heart, your kidneys, undergo a considerable amount of stress and injury,” Martin said. “From a research standpoint, I’m really interested in how we can better educate runners—not only to improve performance, but also to decrease the injury risk and stress associated with marathon running.”

A Quinnipiac professor works with a patient on a bike

Active research

Thomas Martin, associate professor of biomedical sciences, left, and one of the lead researchers for this study, focuses his other research on many aspects of human performance, often dealing with the risks associated with anterior cruciate ligament (ACL) damage.

With more than 500,000 Americans expected to run a marathon this year, this research is both timely and provocative. Although kidney function usually returns to normal within 48 hours of completing a marathon, Martin and the other researchers wanted to know more.

They wondered about the cumulative impact of acute kidney injury on athletes who run dozens of marathons over their lifetimes. They wanted to learn more about the effect of AKI on runners based on age, gender and training regimen after high-intensity marathon running for four hours.

“What we saw in the marathon runners is what we see in a hospital with patients whose kidneys have been compromised by medical and surgical complications,” said Dr. Chirag Parikh of Yale, a professor of medicine. “It was surprising and alarming at the same time, although the recovery was brisk and prompt.”

The researchers studied blood and urine samples taken before the marathon, within 30 minutes after finishing the event and the day after finishing. They discovered 82 percent of the study’s participants presented for Stage 1 acute kidney injury, a mild decline in the kidneys’ ability to filter the body’s waste

“Over the past few years, I’ve been very fortunate to conduct a number of studies at the Hartford Marathon,” said Martin, who has run three marathons himself. “Studies like this are challenging because of recruitment and because we’re collecting data at multiple sites on multiple days in Hartford and here at Quinnipiac. There are a lot of logistics that go into these studies, but they’re so rewarding afterward because of the impact they have on our students and the subjects.”

Others from the Quinnipiac community who worked on the studies include Johanna D’Addario, clinical assistant professor of physician assistant studies; Richard Feinn, associate professor of medical sciences; and students David Jou, Rebecca Kingston, Amanda Lafalce, Kelly Malloy, John Martin-Beaulleu Gabriella Narowska and Lauren Yuknis.