Lise R. Thomas
Professor of Biology
BA, Swarthmore College; PhD, Harvard University
College of Arts & Sciences
I am currently an Associate Professor of Biological Sciences at Quinnipiac University. My formal training is as a molecular neurobiologist, and my teaching focuses at the molecular and cellular level.
Bio 101 General Biology I; Bio 101L General Biology I Lab; Bio 212L Anatomy and Physiology II Lab; Bio 240 Cellular Communication; Bio 329 Neurobiology; Bio 346 Cell Physiology; Bio 346L Cell Physiology Lab; Bio 399H Honors Research in Biological Sciences; Bio 598 Neurophysiology; Bio 606 Molecular and Cellular Laboratories II
B.A. 1987 Swarthmore College (Mathematics and Biology); M.S. 1989 University of Colorado Health Sciences Center (Pharmacology); Ph.D. 1993 Harvard University (Neuroscience); Postdoc 1993-1994 Harvard Medical School (Neurobiology); Postdoc 1994-1999 Brandeis University (Biochemistry)
I am interested in the basic questions of how proteins transport cations across cellular membranes: How is selectivity determined? What conformational rearrangements are necessary for translocation? How is transport activity regulated by cellular conditions? One line of research in my lab focuses on transporters that are located in intracellular organelles, in specific, calcium transporters of the vacuolar compartment of the budding yeast Saccharomyces cerevisiae. This process is particularly amenable for several reasons. First, it is a biologically important problem: intracellular calcium is vital in many cellular processes, and its concentration is tightly controlled by sequestration or release from a variety of intracellular organelles using ion channels or transporters. Second, these intracellular calcium transport proteins are well-suited for attack by classic biochemical and functional methods particularly appropriate for undergraduate researchers. We are starting by addressing very basic questions of membrane topology, with the ultimate goal of understanding the molecular basis of transport (including selectivity & stoichiometry), as well as how activity is regulated.