Quinnipiac University
Alexandre de Lencastre

Associate Professor of Biology

Director of Graduate Program in Molecular and Cell Biology

Alexandre de Lencastre, PhD, was born and raised in Portugal. He is currently an Associate Professor of Biology and Director of the Molecular and Cell Biology Masters Program. He completed his BS in Biochemistry from Georgetown University, his PhD in the lab of Dr. Anna Pyle at Columbia University and was a post-doctoral fellow in the lab of Dr. Frank Slack at Yale University. His teaching focuses on Genetics, Biochemistry and Molecular Biology and he maintains an active research lab that utilizes the model organism C. elegans to study aging and neurodegeneration.

The de Lencastre lab is interested in the roles of microRNAs (miRNAs) and other non-coding RNAs in biology – with emphasis on roles in stress resistance during adulthood. The de Lencastre lab has identified miRNAs that dramatically affect animal lifespan and stress resistance. Currently, the lab is testing the molecular targets of these miRNAs and if they may have related functions in models of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s disease. Given the high conservation of miRNAs across species, insights from this research may inform on diseases of aging in humans.
For more information please visit the de Lencastre lab website:

Welcomes Media Inquiries


  • PHD, Columbia University

Areas of Expertise

  • Genetics
  • Biochemistry
  • Molecular Biology
  • Aging
  • Neurodegenerative diseases - Alzheimer’s, Parkinson’s and Huntington’s disease


  • Biological Sciences

Office Location

  • Buckman Center BC121A

Mail Drop

  • BC-SCI


Quinnipiac University

Associate Professor of Biology

Hamden, CT, USA

2018 - Present

Quinnipiac University

Assistant Professor of Biology

Hamden, CT, USA

2013 - 2018

Yale University

Post-doctoral fellow

New Haven, CT, USA

2006 - 2013

Columbia University

Graduate student instructor

New York, NY, USA

1998 - 2005

Selected Publications

A microRNA feedback loop regulates global microRNA abundance during aging

Inukai S, Pincus Z, de Lencastre A, and Slack FJ

24(2) RNA 159-172 (2018)

An Investigative Graduate Laboratory Course for Teaching Modern DNA Techniques

de Lencastre A, Torello T, Keller L

45(4) Biochemistry and Molecular Biology Education 351-359. (2017)

Alzheimer’s disease: presence and role of microRNAs

Basavaraju M and de Lencastre A

4 BioMolecular Concepts Journal 241-52 (2016)